Tag: rna

PALI-2108 demonstrated to be safe and well tolerated with no serious adverse events (SAEs)

Cayman Islands, July 31, 2025 (GLOBE NEWSWIRE) -- Silexion Therapeutics Corp. (NASDAQ: SLXN) (“Silexion Therapeutics” or the “Company”), a clinical-stage biotech company developing RNA interference (RNAi) therapies for KRAS-driven cancers, today announced the entry into definitive agreements for the immediate exercise of certain outstanding warrants to purchase up to an aggregate of 152,106 of the Company’s ordinary shares originally issued in January 2025 at a reduced exercise price of $11.57 per share. The ordinary shares issuable upon exercise of the warrants are registered pursuant to an effective registration statement on Form S-1 (File No. 333-282932) and an effective resale registration statement on Form S-1 (No. 333-284873). The gross proceeds to the Company from the exercise of the warrants are expected to be approximately $1.8 million, prior to deducting placement agent fees and estimated offering expenses. The offering is expected to close on or about August 1, 2025, subject to satisfaction of customary closing conditions. The Company intends to use the net proceeds from the offering as working capital for general corporate purposes.

New Iso-Seq data from ~1,000 samples to expand transcriptomic insights using highly accurate HiFi sequencing

數據支持進一步評估試驗性的反義寡核苷酸 OT-101 (trabedersen) 作為胰臟導管腺癌中 TGFB2- 標靶治療方案的效果。

现有数据支持进一步评估在研反义药物 OT-101（又名 trabedersen）作为靶向 TGFB2 -的治疗策略，用于胰腺导管腺癌的疗效。