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Information relative au nombre total des droits de vote et
d’actions composant le capital social au 31 juillet 2025

Basel, 01 August 2025 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today new, five-year efficacy, safety and durability data from the Phase III Portal study, a long-term extension of the Phase III Archway study, of Susvimo® (ranibizumab injection) for the treatment of people with nAMD.¹ Results show that Susvimo’s immediate and predictable durability was sustained over five years, with approximately 95% of people receiving treatment every six months requiring no supplemental treatment before each refill. The data were presented at the American Society of Retina Specialists (ASRS) 2025 Annual Meeting in Long Beach, California, United States.

This news release constitutes a "Designated News Release" incorporated by reference in the prospectus supplement dated December 9, 2024 to Fortis' short form base shelf prospectus dated December 9, 2024.

The global adhesives and sealants market size is expected to be worth USD 126.50 billion by 2034, increasing from USD 76.53 billion in 2025 and is growing at a CAGR of 5.75% from 2025 to 2034, fueled by green construction, EV adoption, and packaging innovations.