Tag: allergy

– Verekitug, administered once every three months, led to clinically meaningful improvements in nasal polyp score (NPS) in approximately 80% of participants –

HAMPTON, N.J., June 14, 2026 (GLOBE NEWSWIRE) -- Celldex (NASDAQ:CLDX) today presented positive results from the Phase 1 healthy participant study of CDX-622, a novel, bispecific antibody that targets soluble SCF and TSLP, at the European Academy of Allergy and Clinical Immunology (EAACI) Annual Meeting in Istanbul, Türkiye. Data demonstrated that CDX-622 induced rapid, durable, dose-dependent reductions in serum tryptase, indicative of mast cell depletion, and was well-tolerated at all dose levels. Building on Celldex’s leadership in mast cell science, the data also demonstrated that neutralizing soluble stem cell factor (SCF) enables the potential for meaningful mast cell inhibition and depletion without impacting other KIT-dependent functions. CDX-622 is currently being studied in a Phase 1b proof of mechanism study in mild to moderate asthma to assess the impact of dual neutralization of SCF and TSLP.

Réunis à Istanbul, des spécialistes de renom en allergologie exploreront les moyens par lesquels la science, la prévention et les politiques peuvent réduire l’impact mondial des maladies allergiques

Führende Allergieexperten treffen sich in Istanbul, um zu erörtern, wie Wissenschaft, Prävention und Politik die weltweiten Auswirkungen allergischer Erkrankungen verringern können

מומחי אלרגיה מובילים יתכנסו באיסטנבול כדי לבחון כיצד מדע, מניעה ומדיניות יכולים להפחית את ההשפעה הגלובלית של מחלות אלרגיות.

Para ahli energi terkemuka berkumpul di Istanbul untuk membahas secara lebih mendalam bagaimana sains, pencegahan, dan kebijakan dapat mengurangi dampak penyakit alergi di tingkat global

アレルギー分野の第一線の専門家がイスタンブールに集結し、科学、予防、政策がいかにしてアレルギー疾患の世界的な影響を軽減できるかを検討する

Pakar alahan terkemuka akan berhimpun di Istanbul untuk meneroka bagaimana sains, pencegahan dan dasar awam dapat mengurangkan beban global penyakit alahan

全球顶尖过敏学专家将齐聚伊斯坦布尔，共同探讨如何借助科学、预防和政策，减轻过敏性疾病在全球带来的影响

頂尖過敏症專家匯聚伊斯坦堡，探討如何通過科學、預防和政策來減輕過敏疾病對全球的影響

Basel, June 12, 2026 – Novartis today presented data from the RemIND trial at the European Academy of Allergy and Clinical Immunology (EAACI) Congress showing that Rhapsido^®  (remibrutinib) met its primary endpoints across the three most common chronic inducible urticaria (CIndU) subtypes, becoming the first-ever treatment to demonstrate efficacy in a global Phase III CIndU clinical trial⁷. In the RemIND trial, higher rates of complete responses were observed at week 12, with responses seen as early as week 2 in two subtypes. These results demonstrate that Rhapsido may provide sustained relief for patients whose disease remains inadequately controlled after treatment with second-generation H1-antihistamines⁷.

“Chronic inducible urticaria (CIndU) is a form of chronic hives in which everyday triggers—such as pressure, heat, cold, or sunlight—can lead to itchy wheals, and there are currently no approved targeted treatment options,” said Prof. Dr. med. Martin Metz, Deputy Director, Institute of Allergology, Charité–Universitätsmedizin Berlin, Germany. “The RemIND results across the three most common CIndU subtypes highlight the potential of Rhapsido as an important new treatment option for patients with significant unmet need.”

The three most prevalent CIndU subtypes are symptomatic dermographism (SD), cold urticaria, and cholinergic urticaria, with SD being the most common⁸. Novartis has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) seeking approval of Rhapsido for the treatment of SD subtype and will continue additional filings to health authorities globally throughout 2026. Rhapsido is approved for use in the U.S., European Union, China and several other countries for the treatment of chronic spontaneous urticaria (CSU), in adult patients with inadequate response to H1-antihistamines.

“Rhapsido significantly improves symptom control for patients living with the three most common subtypes of chronic inducible urticaria, and it has the potential to become the first approved targeted therapy. This is a major step forward for CIndU patients who have limited options,” said Angelika Jahreis, Global Head, Immunology Development, Novartis. “The CIndU data presented today are consistent with Rhapsido’s proven efficacy and favorable safety profile in chronic spontaneous urticaria and demonstrate Novartis’ commitment to developing truly meaningful innovation for patients with complex immune-mediated diseases.”

Primary endpoint results at Week 12 in the RemIND trial¹

Leading allergy experts to convene in Istanbul to explore how science, prevention and policy can reduce the global impact of allergic diseases